ea0065p1 | Adrenal and Cardiovascular | SFEBES2019
McGinnis Kathryn
, Baker Syed Murtuza
, Donaldson Ian
, Berry Andrew
, Rattray Magnus
, Ray David
, Stead Lucy
, Cook Graham
, Bond Jacquelyn
, Matthews Laura
Synthetic glucocorticoids (Gc) are the most potent anti-inflammatory agents known and are widely used to treat a range of chronic inflammatory diseases including rheumatoid arthritis and asthma. However their therapeutic utility is limited by the development of Gc resistance over time particularly at sites of inflammation. Understanding the underlying mechanisms that control Gc sensitivity is essential to overcome this. Previous studies have measured the average transcr...